Lineage for d1ml3d1 (1ml3 D:1-164,D:334-359)

  1. Root: SCOP 1.71
  2. 570216Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
  3. 574151Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 574152Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) (S)
  5. 575085Family c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (18 proteins)
    family members also share a common alpha+beta fold in C-terminal domain
  6. 575246Protein Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) [51801] (16 species)
  7. 575401Species Trypanosoma cruzi [TaxId:5693] [75104] (3 PDB entries)
  8. 575409Domain d1ml3d1: 1ml3 D:1-164,D:334-359 [85007]
    Other proteins in same PDB: d1ml3a2, d1ml3b2, d1ml3c2, d1ml3d2
    complexed with cyx, nad

Details for d1ml3d1

PDB Entry: 1ml3 (more details), 2.5 Å

PDB Description: Evidences for a flip-flop catalytic mechanism of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, from its crystal structure in complex with reacted irreversible inhibitor 2-(2-phosphono-ethyl)-acrylic acid 4-nitro-phenyl ester

SCOP Domain Sequences for d1ml3d1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1ml3d1 c.2.1.3 (D:1-164,D:334-359) Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) {Trypanosoma cruzi}

SCOP Domain Coordinates for d1ml3d1:

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(The format of our PDB-style files is described here.)

Timeline for d1ml3d1: