SCOP 1.73: Domain d1h1wa_: 1h1w A:

Lineage for d1h1wa_ (1h1w A:)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
   AGC group; PBK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [90037] (12 PDB entries)

8. Domain d1h1wa_: 1h1w A: [83460]
   complexed with atp, gol, sep, so4

Details for d1h1wa_

PDB Entry: 1h1w, 2 Å

PDB Description: high resolution crystal structure of the human pdk1 catalytic domain

PDB Compounds: (A:) 3-phosphoinositide dependent protein kinase-1

SCOP Domain Sequences for d1h1wa_:

Sequence, based on SEQRES records:

>d1h1wa_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
ppqprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtre
rdvmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeiv
saleylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvs
pellteksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkar
dlvekllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt

Sequence, based on observed residues (ATOM records):

>d1h1wa_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
ppqprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtre
rdvmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeiv
saleylhgkgiihrdlkpenillnedmhiqitdfgtakvlsparansfvgtaqyvspell
teksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlve
kllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt

Timeline for d1h1wa_:

• d1h1wa_ first appeared in SCOP 1.65
  
• d1h1wa_ appears in SCOP 1.71
  
• d1h1wa_ appears in SCOP 1.75
  
• d1h1wa_ appears in the current release, SCOPe 2.08