SCOP 1.73: Domain d1h01a_: 1h01 A:

Lineage for d1h01a_ (1h01 A:)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (124 PDB entries)

8. Domain d1h01a_: 1h01 A: [83410]
   complexed with fal, fbl, gol, kcx

Details for d1h01a_

PDB Entry: 1h01, 1.79 Å

PDB Description: cdk2 in complex with a disubstituted 2, 4-bis anilino pyrimidine cdk4 inhibitor

PDB Compounds: (A:) Cell division protein kinase 2

SCOP Domain Sequences for d1h01a_:

Sequence, based on SEQRES records:

>d1h01a_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Sequence, based on observed residues (ATOM records):

>d1h01a_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirstaireisllkelnhpnivklldv
ihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdlk
pqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyystavdiwsl
gcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfs
kvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Timeline for d1h01a_:

• d1h01a_ first appeared in SCOP 1.65
  
• d1h01a_ appears in SCOP 1.71
  
• d1h01a_ appears in SCOP 1.75
  
• d1h01a_ appears in the current release, SCOPe 2.08