SCOPe 2.01: Domain d1gzka_: 1gzk A:

Lineage for d1gzka_ (1gzk A:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Pkb kinase (Akt-2) [82791] (1 species)
   AGC group; RAC/Akt subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82792] (16 PDB entries)

8. Domain d1gzka_: 1gzk A: [83406]

Details for d1gzka_

PDB Entry: 1gzk, 2.3 Å

PDB Description: molecular mechanism for the regulation of protein kinase b/ akt by hydrophobic motif phosphorylation

PDB Compounds: (A:) rac-beta serine/threonine protein kinase

SCOPe Domain Sequences for d1gzka_:

Sequence, based on SEQRES records:

>d1gzka_ d.144.1.7 (A:) Pkb kinase (Akt-2) {Human (Homo sapiens) [TaxId: 9606]}
kvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvtesrvlq
ntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaley
lhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylapevledn
dygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksllagll
kkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfdd

Sequence, based on observed residues (ATOM records):

>d1gzka_ d.144.1.7 (A:) Pkb kinase (Akt-2) {Human (Homo sapiens) [TaxId: 9606]}
kvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkevivtesrvlqntrhpflta
lkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaleylhsrdvvyr
diklenlmldkdghikitdfgltpeylapevledndygravdwwglgvvmyemmcgrlpf
ynqdherlfelilmeeirfprtlspeaksllagllkkdpkqrlgggpsdakevmehrffl
sinwqdvvqkkllppfkpqvtsevdtryfdd

Timeline for d1gzka_:

• d1gzka_ first appeared in SCOP 1.65
  
• d1gzka_ appears in SCOP 1.75
  
• d1gzka_ appears in SCOPe 2.02
  
• d1gzka_ appears in the current release, SCOPe 2.08