SCOP 1.65: Domain d1gz3a1: 1gz3 A:280-573

Lineage for d1gz3a1 (1gz3 A:280-573)

1. Root: SCOP 1.65

2. Class c: Alpha and beta proteins (a/b) [51349] (121 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families)

5. Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (10 proteins)
   extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

6. Protein Mitochondrial NAD(P)-dependenent malic enzyme [51898] (3 species)
   includes C-terminal additional subdomains

7. Species Human (Homo sapiens) [TaxId:9606] [51899] (7 PDB entries)

8. Domain d1gz3a1: 1gz3 A:280-573 [83393]
   Other proteins in same PDB: d1gz3a2, d1gz3b2, d1gz3c2, d1gz3d2

Details for d1gz3a1

PDB Entry: 1gz3, 2.3 Å

PDB Description: molecular mechanism for the regulation of human mitochondrial nad(p)+- dependent malic enzyme by atp and fumarate

SCOP Domain Sequences for d1gz3a1:

Sequence; same for both SEQRES and ATOM records:

>d1gz3a1 c.2.1.7 (A:280-573) Mitochondrial NAD(P)-dependenent malic enzyme {Human (Homo sapiens)}
iqgtaavalagllaaqkviskpisehkilflgageaalgianlivmsmvenglseqeaqk
kiwmfdkygllvkgrkakidsyqepfthsapesipdtfedavnilkpstiigvagagrlf
tpdviramasinerpvifalsnptaqaectaeeaytltegrclfasgspfgpvkltdgrv
ftpgqgnnvyifpgvalavilcntrhisdsvfleaakaltsqltdeelaqgrlypplani
qevsiniaikvteylyankmafvypepedkakyvkeqtwrseydsllpdvyewp

Timeline for d1gz3a1:

• d1gz3a1 is new in SCOP 1.65
  
• d1gz3a1 appears in SCOP 1.67
  
• d1gz3a1 appears in the current release, SCOPe 2.08