Lineage for Protein: Angiotensin converting enzyme, ACE

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1917420Fold d.92: Zincin-like [55485] (2 superfamilies)
    contains mixed beta sheet with connection over free side of the sheet
  4. 1917421Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families) (S)
  5. 1917605Family d.92.1.5: Neurolysin-like [55505] (5 proteins)
    combines M2, M3 and M32 families of metalloproteases
    the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain
  6. 1917627Protein Angiotensin converting enzyme, ACE [82733] (2 species)
    M2 family member; overall fold is similar to that of neurolysin but is less elaborated


  1. 1917628Fruit fly (Drosophila melanogaster) [TaxId:7227] [89991] (3 PDB entries)
    1. Domains for 1j36:
      1. 1917629Domain d1j36a_: 1j36 A: [84054]
        complexed with lpr, zn
      2. 1917630Domain d1j36b_: 1j36 B: [84055]
        complexed with lpr, zn
    2. Domains for 1j37:
      1. 1917631Domain d1j37a_: 1j37 A: [84056]
        complexed with x8z, zn
      2. 1917632Domain d1j37b_: 1j37 B: [84057]
        complexed with x8z, zn
    3. Domains for 1j38:
      1. 1917633Domain d1j38a_: 1j38 A: [84058]
        complexed with zn
      2. 1917634Domain d1j38b_: 1j38 B: [84059]
        complexed with zn
  2. 1917635Human (Homo sapiens) [TaxId:9606] [82734] (11 PDB entries)
    Uniprot P22966
    1. Domain for 1o86:
    2. Domain for 1o8a:
    3. Domain for 1uze:
    4. Domain for 1uzf:
    5. Domain for 2oc2:
    6. Domain for 2xy9:
    7. Domain for 3bkk:
    8. Domain for 3bkl:
    9. Domain for 3l3n:
    10. Domain for 4bzr:
    11. Domain for 4ca5:

More info for Protein Angiotensin converting enzyme, ACE from d.92.1.5: Neurolysin-like

Timeline for Protein Angiotensin converting enzyme, ACE from d.92.1.5: Neurolysin-like: