SCOP 1.75: Family a.77.1.3: Caspase recruitment domain, CARD

Lineage for Family a.77.1.3: Caspase recruitment domain, CARD

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.77: DEATH domain [47985] (1 superfamily)
   6 helices: closed bundle; greek-key; internal pseudo twofold symmetry

4. Superfamily a.77.1: DEATH domain [47986] (4 families)

5. Family a.77.1.3: Caspase recruitment domain, CARD [81313] (5 proteins)

Proteins:

1. Apoptotic protease activating factor 1, APAF-1 [47997] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47998] (6 PDB entries)

2. Cell death protein 4, CED-4 [158663] (1 species)

   • Species Caenorhabditis elegans [TaxId:6239] [158664] (1 PDB entry)
     Uniprot P30429 1-108

3. Iceberg [48001] (1 species)
   an inhibitor of interleukin-1beta generation

   • Species Human (Homo sapiens) [TaxId:9606] [48002] (1 PDB entry)

4. Procaspase 9 prodomain [47999] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [48000] (1 PDB entry)

5. Raidd CARD domain [47995] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47996] (1 PDB entry)

More info for Family a.77.1.3: Caspase recruitment domain, CARD

Timeline for Family a.77.1.3: Caspase recruitment domain, CARD:

• Family a.77.1.3: Caspase recruitment domain, CARD first appeared in SCOP 1.63
  
• Family a.77.1.3: Caspase recruitment domain, CARD appears in SCOP 1.73
  
• Family a.77.1.3: Caspase recruitment domain, CARD appears in SCOPe 2.01
  
• Family a.77.1.3: Caspase recruitment domain, CARD appears in the current release, SCOPe 2.08