SCOPe 2.02: Domain d1mzne_: 1mzn E:

Lineage for d1mzne_ (1mzn E:)

1. Root: SCOPe 2.02

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Retinoid-X receptor alpha (RXR-alpha) [48510] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48511] (33 PDB entries)
   Uniprot P19793 227-458

8. Domain d1mzne_: 1mzn E: [79706]
   complexed with co-activator peptide
   complexed with bm6

Details for d1mzne_

PDB Entry: 1mzn, 1.9 Å

PDB Description: crystal structure at 1.9 angstroems resolution of the homodimer of human rxr alpha ligand binding domain bound to the synthetic agonist compound bms 649 and a coactivator peptide

PDB Compounds: (E:) RXR retinoid X receptor

SCOPe Domain Sequences for d1mzne_:

Sequence, based on SEQRES records:

>d1mzne_ a.123.1.1 (E:) Retinoid-X receptor alpha (RXR-alpha) {Human (Homo sapiens) [TaxId: 9606]}
nedmpverileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlvewakri
phfselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsagvgaif
drvltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasleayckh
kypeqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemleap

Sequence, based on observed residues (ATOM records):

>d1mzne_ a.123.1.1 (E:) Retinoid-X receptor alpha (RXR-alpha) {Human (Homo sapiens) [TaxId: 9606]}
nedmpverileaelavepktetyveanndpvtnicqaadkqlftlvewakriphfselpl
ddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsagvgaifdrvltelv
skmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasleayckhkypeqpgr
faklllrlpalrsiglkclehlfffkligdtpidtflmemleap

Timeline for d1mzne_:

• d1mzne_ first appeared in SCOP 1.63
  
• d1mzne_ appears in SCOPe 2.01
  
• d1mzne_ appears in SCOPe 2.03
  
• d1mzne_ appears in the current release, SCOPe 2.08