SCOP 1.63: Domain d1lwfb_: 1lwf B:

Lineage for d1lwfb_ (1lwf B:)

1. Root: SCOP 1.63

2. Class e: Multi-domain proteins (alpha and beta) [56572] (39 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (2 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (63 PDB entries)

8. Domain d1lwfb_: 1lwf B: [78272]
   Other proteins in same PDB: d1lwfa1
   complexed with csd, nvp; mutant

Details for d1lwfb_

PDB Entry: 1lwf, 2.8 Å

PDB Description: crystal structure of a mutant hiv-1 reverse transcriptase (rtmq+m184v: m41l/d67n/k70r/m184v/t215y) in complex with nevirapine

SCOP Domain Sequences for d1lwfb_:

Sequence, based on SEQRES records:

>d1lwfb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
etvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpvfaikk
knstrwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfr
kytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqyvd
dlyvgsdleigqhrtkieelrqhllrwglytpdkkhqkeppflwmgyelhpdkwtvqpiv
lpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelae
nreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndv
kqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvkl
wyq

Sequence, based on observed residues (ATOM records):

>d1lwfb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
etvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpvfaikk
knstrwrklvdfrelnkrtqdfhpaglkkkksvtvldvgdayfsvpldedfrkytaftip
sinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqyvddlyvgsdl
eigqhrtkieelrqhllrwelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypg
ikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqg
qgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfklpi
qketwetwwteywqatwipewefvntpplvklwyq

Timeline for d1lwfb_:

• d1lwfb_ is new in SCOP 1.63
  
• d1lwfb_ appears in SCOP 1.65
  
• d1lwfb_ appears in the current release, SCOPe 2.08