SCOP 1.69: Domain d1lwfa2: 1lwf A:1-429

Lineage for d1lwfa2 (1lwf A:1-429)

1. Root: SCOP 1.69

2. Class e: Multi-domain proteins (alpha and beta) [56572] (46 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (2 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (78 PDB entries)

8. Domain d1lwfa2: 1lwf A:1-429 [78271]
   Other proteins in same PDB: d1lwfa1

Details for d1lwfa2

PDB Entry: 1lwf, 2.8 Å

PDB Description: crystal structure of a mutant hiv-1 reverse transcriptase (rtmq+m184v: m41l/d67n/k70r/m184v/t215y) in complex with nevirapine

SCOP Domain Sequences for d1lwfa2:

Sequence, based on SEQRES records:

>d1lwfa2 e.8.1.2 (A:1-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
pispietvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpv
faikkknstrwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqyvddlyvgsdleigqhrtkieelrqhllrwglytpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlakllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyql

Sequence, based on observed residues (ATOM records):

>d1lwfa2 e.8.1.2 (A:1-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
pispietvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpv
faikklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrkyt
aftipnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqyvddlyvgs
dleigqhrtkieelrqhllrwglytpdkkhqkeppflwmgyelhpdkwtvqpivlpekds
wtvndiqklvgklnwasqiypgikvrqlakllrgtkalteviplteeaelelaenreilk
epvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqltea
vqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyql

Timeline for d1lwfa2:

• d1lwfa2 first appeared in SCOP 1.63
  
• d1lwfa2 appears in SCOP 1.67
  
• d1lwfa2 appears in SCOP 1.71
  
• d1lwfa2 appears in the current release, SCOPe 2.08