SCOP 1.63: Domain d1lwea2: 1lwe A:1-429

Lineage for d1lwea2 (1lwe A:1-429)

1. Root: SCOP 1.63

2. Class e: Multi-domain proteins (alpha and beta) [56572] (39 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (2 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (63 PDB entries)

8. Domain d1lwea2: 1lwe A:1-429 [78268]
   Other proteins in same PDB: d1lwea1
   complexed with csd, nvp, po4; mutant

Details for d1lwea2

PDB Entry: 1lwe, 2.81 Å

PDB Description: crystal structure of m41l/t215y mutant hiv-1 reverse transcriptase (rtmn) in complex with nevirapine

SCOP Domain Sequences for d1lwea2:

Sequence, based on SEQRES records:

>d1lwea2 e.8.1.2 (A:1-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
pispietvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglytpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlakllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyql

Sequence, based on observed residues (ATOM records):

>d1lwea2 e.8.1.2 (A:1-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
pispietvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpv
faikkstkklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedf
rkytaftipsiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgs
dleigqhrtkieelrqhllrwglytpdkkhqkeppflwmgyelhpdkwtvqpivlpekds
wtvndiqklvgklnwasqiypgikvrqlakllrgtkalteviplteeaelelaenreilk
epvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqltea
vqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyql

Timeline for d1lwea2:

• d1lwea2 is new in SCOP 1.63
  
• d1lwea2 appears in SCOP 1.65
  
• d1lwea2 appears in the current release, SCOPe 2.08