SCOPe 2.05: Domain d1kwpa_: 1kwp A:

Lineage for d1kwpa_ (1kwp A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
   CaMK group; MAPKAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82790] (15 PDB entries)

8. Domain d1kwpa_: 1kwp A: [77573]
   complexed with hg

Details for d1kwpa_

PDB Entry: 1kwp, 2.8 Å

PDB Description: crystal structure of mapkap2

PDB Compounds: (A:) MAP Kinase Activated Protein Kinase 2

SCOPe Domain Sequences for d1kwpa_:

Sequence, based on SEQRES records:

>d1kwpa_ d.144.1.7 (A:) MAP kinase activated protein kinase 2, mapkap2 {Human (Homo sapiens) [TaxId: 9606]}
fhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrev
elhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafterease
imksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettshnslttpcy
tpyyvapevlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqye
fpnpewsevseevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlked
kerwedvkeemtsalatmrvdyeqikikkiedasnplllk

Sequence, based on observed residues (ATOM records):

>d1kwpa_ d.144.1.7 (A:) MAP kinase activated protein kinase 2, mapkap2 {Human (Homo sapiens) [TaxId: 9606]}
fhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrev
elhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafterease
imksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettsgpekydksc
dmwslgvimyillcgyppfysnhglaispgmktrirmyefpnpewsevseevkmlirnll
kteptqrmtitefmnhpwimqstkvpqtplhtsrvlkedkerwedvkeemtsalatmrvd
yeqikikkiedasnplllk

Timeline for d1kwpa_:

• d1kwpa_ first appeared in SCOP 1.63
  
• d1kwpa_ appears in SCOPe 2.04
  
• d1kwpa_ appears in SCOPe 2.06
  
• d1kwpa_ appears in the current release, SCOPe 2.08