SCOPe 2.01: Domain d1it9h2: 1it9 H:122-219

Lineage for d1it9h2 (1it9 H:122-219)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88575] (172 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody

8. Domain d1it9h2: 1it9 H:122-219 [76784]
   Other proteins in same PDB: d1it9h1, d1it9l1, d1it9l2
   part of humanized anti-human Fas Fab HFE7A

Details for d1it9h2

PDB Entry: 1it9, 2.8 Å

PDB Description: crystal structure of an antigen-binding fragment from a humanized version of the anti-human fas antibody hfe7a

PDB Compounds: (H:) humanized antibody hfe7a, heavy chain

SCOPe Domain Sequences for d1it9h2:

Sequence; same for both SEQRES and ATOM records:

>d1it9h2 b.1.1.2 (H:122-219) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkv

Timeline for d1it9h2:

• d1it9h2 first appeared in SCOP 1.63
  
• d1it9h2 appears in SCOP 1.75
  
• d1it9h2 appears in SCOPe 2.02
  
• d1it9h2 appears in the current release, SCOPe 2.08