Class b: All beta proteins [48724] (176 folds) |
Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies) sandwich; 7 strands in 2 sheets; greek-key some members of the fold have additional strands |
Superfamily b.1.1: Immunoglobulin [48726] (5 families) |
Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins) |
Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species) VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species |
Species Engineered (including hybrid species) [88562] (68 PDB entries) SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # humanized antibody ! SQ NA # Humanized antibody ! SQ NA # engineered antibody |
Domain d1it9h1: 1it9 H:1-121 [76783] Other proteins in same PDB: d1it9h2, d1it9l1, d1it9l2 part of humanized anti-human Fas Fab HFE7A |
PDB Entry: 1it9 (more details), 2.8 Å
SCOPe Domain Sequences for d1it9h1:
Sequence; same for both SEQRES and ATOM records: (download)
>d1it9h1 b.1.1.1 (H:1-121) Immunoglobulin heavy chain variable domain, VH {Engineered (including hybrid species)} qvqlvqsgaevkkpgasvkvsckasgytftsywmqwvkqapgqglewmgeidpsdsytny nqkfkgkatltvdtststaymelsslrsedtavyycarnrdysnnwyfdvwgegtlvtvs s
Timeline for d1it9h1: