SCOP 1.71: Domain d1gwrb_: 1gwr B:

Lineage for d1gwrb_ (1gwr B:)

1. Root: SCOP 1.71

2. Class a: All alpha proteins [46456] (226 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (1 family)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (32 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (19 PDB entries)

8. Domain d1gwrb_: 1gwr B: [76369]
   complex with 17beta-oestradiol and TIF2 NRbox3 peptide; chains C and D
   complexed with est

Details for d1gwrb_

PDB Entry: 1gwr, 2.4 Å

PDB Description: human oestrogen receptor alpha ligand-binding domain in complex with 17beta-oestradiol and tif2 nrbox3 peptide

SCOP Domain Sequences for d1gwrb_:

Sequence, based on SEQRES records:

>d1gwrb_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens)}
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitd
tlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydllleml
dahr

Sequence, based on observed residues (ATOM records):

>d1gwrb_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens)}
slalsltadqmvsalldaeppilyseydppfseasmmglltnladrelvhminwakrvpg
fvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifd
mllatssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldkitdtlihl
makagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydlllemldahr

Timeline for d1gwrb_:

• d1gwrb_ first appeared in SCOP 1.63
  
• d1gwrb_ appears in SCOP 1.69
  
• d1gwrb_ appears in SCOP 1.73
  
• d1gwrb_ appears in the current release, SCOPe 2.08