Lineage for Family c.116.1.2: Hypothetical protein MTH1 (MT0001), dimerisation domain

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.116: alpha/beta knot [75216] (1 superfamily) core: 3 layers: a/b/a, parallel beta-sheet of 5 strands, order 21435; contains a deep trefoil knot

4. Superfamily c.116.1: alpha/beta knot [75217] (9 families) known or predicted SAM-dependent methytransferases including the SPOUT 'sequence' superfamily all known members have dimeric structures

5. Family c.116.1.2: Hypothetical protein MTH1 (MT0001), dimerisation domain [75221] (1 protein) contains extra strand (3) in the parallel beta-sheet, order 321546; interrupted by an insert OB-fold domain