Class a: All alpha proteins [46456] (290 folds) |
Fold a.26: 4-helical cytokines [47265] (1 superfamily) core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections |
Superfamily a.26.1: 4-helical cytokines [47266] (4 families) there are two different topoisomers of this fold with different entanglements of the two crossover connections |
Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 proteins) contains an additional helix in one of the crossover connections |
Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species) intertwined dimer, similar to interferon-gamma |
Species Human herpesvirus 5 [TaxId:10359] [74708] (1 PDB entry) |
Domain d1lqsl_: 1lqs L: [74192] Other proteins in same PDB: d1lqsr1, d1lqsr2, d1lqss1, d1lqss2 complexed with nag |
Domain d1lqsm_: 1lqs M: [74193] Other proteins in same PDB: d1lqsr1, d1lqsr2, d1lqss1, d1lqss2 complexed with nag |
Timeline for Species Human herpesvirus 5 [TaxId:10359] from a.26.1.3 Interleukin-10 (cytokine synthesis inhibitory factor, CSIF):