SCOP 1.67: Domain d1m6ia1: 1m6i A:128-263,A:401-477

Lineage for d1m6ia1 (1m6i A:128-263,A:401-477)

1. Root: SCOP 1.67

2. Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (5 families)

5. Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains [51943] (12 proteins)
   duplication: both domains have similar folds and functions
   most members of the family contain common C-terminal alpha+beta domain

6. Protein Apoptosis-inducing factor (AIF) [75126] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [75127] (1 PDB entry)

8. Domain d1m6ia1: 1m6i A:128-263,A:401-477 [74533]
   Other proteins in same PDB: d1m6ia3

Details for d1m6ia1

PDB Entry: 1m6i, 1.8 Å

PDB Description: Crystal Structure of Apoptosis Inducing Factor (AIF)

SCOP Domain Sequences for d1m6ia1:

Sequence, based on SEQRES records:

>d1m6ia1 c.3.1.5 (A:128-263,A:401-477) Apoptosis-inducing factor (AIF) {Human (Homo sapiens)}
apshvpflligggtaafaaarsirardpgarvlivsedpelpymrpplskelwfsddpnv
tktlrfkqwngkersiyfqppsfyvsaqdlphienggvavltgkkvvqldvrdnmvklnd
gsqityekcliatggtXepnvelaktggleidsdfggfrvnaelqarsniwvagdaacfy
diklgrrrvehhdhavvsgrlagenmtgaakpyw

Sequence, based on observed residues (ATOM records):

>d1m6ia1 c.3.1.5 (A:128-263,A:401-477) Apoptosis-inducing factor (AIF) {Human (Homo sapiens)}
apshvpflligggtaafaaarsirardpgarvlivsedpelpymrpplskelwfspnvtk
tlrfkqwngkersiyfqppsfyvsaqdlphienggvavltgkkvvqldvrdnmvklndgs
qityekcliatggtXepnvelaktggleidsdfggfrvnaelqarsniwvagdaacfydi
klgrrrvehhdhavvsgrlagenmtgaakpyw

Timeline for d1m6ia1:

• d1m6ia1 first appeared in SCOP 1.61
  
• d1m6ia1 appears in SCOP 1.65
  
• d1m6ia1 appears in SCOP 1.69
  
• d1m6ia1 appears in the current release, SCOPe 2.08