SCOP 1.75: Domain d1lo3x1: 1lo3 X:1-112

Lineage for d1lo3x1 (1lo3 X:1-112)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (32 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1.1 [TaxId:10090] [88524] (127 PDB entries)
   Uniprot P01631 #KV2G_MOUSE Ig kappa chain V-II region 26-10; 79% sequence identity
   Uniprot P06310 # KV2F_HUMAN IG KAPPA CHAIN V-II REGION RPMI 6410 PRECURSOR
   Uniprot P03976 # KV2E_MOUSE (P03976) Ig kappa chain V-II region 17S29.1
   Uniprot P01642 21-115 #
   KV2G_MOUSE IG KAPPA CHAIN V-II REGION 26-10
   Uniprot P01631 #KV2G_MOUSE Ig kappa chain V-II region 26-10; 79% sequence identity ! Uniprot P06310 # KV2F_HUMAN IG KAPPA CHAIN V-II REGION RPMI 6410 PRECURSOR ! Uniprot P03976 # KV2E_MOUSE (P03976) Ig kappa chain V-II region 17S29.1 ! Uniprot P01642 21-115 # ! KV2G_MOUSE IG KAPPA CHAIN V-II REGION 26-10

8. Domain d1lo3x1: 1lo3 X:1-112 [74135]
   Other proteins in same PDB: d1lo3h1, d1lo3h2, d1lo3l2, d1lo3x2, d1lo3y1, d1lo3y2
   part of retro Diels-Alder catalytic Fab 9D9

Details for d1lo3x1

PDB Entry: 1lo3, 2.3 Å

PDB Description: Retro-Diels-Alderase Catalytic Antibody: Product Analogue

PDB Compounds: (X:) If kappa light chain

SCOP Domain Sequences for d1lo3x1:

Sequence; same for both SEQRES and ATOM records:

>d1lo3x1 b.1.1.1 (X:1-112) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 1.1 [TaxId: 10090]}
dvlmtqtplslpvslgdqvsifctssqtivhtngntylewylqkpgqspklliykvsnrf
sgvpdrfsgsgsgtdftlkisrvetedlgiyycfqgshfplafgagtklelk

Timeline for d1lo3x1:

• d1lo3x1 first appeared in SCOP 1.61
  
• d1lo3x1 appears in SCOP 1.73
  
• d1lo3x1 appears in SCOPe 2.01
  
• d1lo3x1 appears in the current release, SCOPe 2.08