SCOPe 2.06: Domain d1lk3m1: 1lk3 M:1-106

Lineage for d1lk3m1 (1lk3 M:1-106)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Norway rat (Rattus norvegicus) [TaxId:10116] [88532] (9 PDB entries)

8. Domain d1lk3m1: 1lk3 M:1-106 [73958]
   Other proteins in same PDB: d1lk3a_, d1lk3b_, d1lk3h1, d1lk3h2, d1lk3i1, d1lk3i2, d1lk3l2, d1lk3m2
   part of anti-IL-10 Fab 9D7

Details for d1lk3m1

PDB Entry: 1lk3, 1.91 Å

PDB Description: engineered human interleukin-10 monomer complexed to 9d7 fab fragment

PDB Compounds: (M:) 9D7 Light Chain

SCOPe Domain Sequences for d1lk3m1:

Sequence; same for both SEQRES and ATOM records:

>d1lk3m1 b.1.1.1 (M:1-106) Immunoglobulin light chain kappa variable domain, VL-kappa {Norway rat (Rattus norvegicus) [TaxId: 10116]}
dtvltqppaltvspgekltisckasesvtsrmhwyqqkpgqqpklliykasnlasgvpar
fsgsgsgtdftltidpveaddtaiyfcqqswngpltfgagtklelk

Timeline for d1lk3m1:

• d1lk3m1 first appeared in SCOP 1.61
  
• d1lk3m1 appears in SCOPe 2.05
  
• d1lk3m1 appears in SCOPe 2.07
  
• d1lk3m1 appears in the current release, SCOPe 2.08