Lineage for d1lk3b_ (1lk3 B:)

  1. Root: SCOP 1.63
  2. 208553Class a: All alpha proteins [46456] (171 folds)
  3. 212476Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 212477Superfamily a.26.1: 4-helical cytokines [47266] (3 families) (S)
    there are two different topoisomers of this fold with different entanglments of the two crossover connections
  5. 212614Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (7 proteins)
    contains an additional helix in one of the crossover connections
  6. 212661Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species)
    intertwined dimer, similar to interferon-gamma
  7. 212664Species Human (Homo sapiens) [TaxId:9606] [47307] (5 PDB entries)
  8. 212668Domain d1lk3b_: 1lk3 B: [73951]
    Other proteins in same PDB: d1lk3h1, d1lk3h2, d1lk3i1, d1lk3i2, d1lk3l1, d1lk3l2, d1lk3m1, d1lk3m2

Details for d1lk3b_

PDB Entry: 1lk3 (more details), 1.91 Å

PDB Description: engineered human interleukin-10 monomer complexed to 9d7 fab fragment

SCOP Domain Sequences for d1lk3b_:

Sequence, based on SEQRES records: (download)

>d1lk3b_ a.26.1.3 (B:) Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) {Human (Homo sapiens)}
nmlrdlrdafsrvktffqmkdqldnlllkeslledfkgylgcqalsemiqfyleevmpqa
enqdpdikahvnslgenlktlrlrlrrchrflpcengggsggkskaveqvknafnklqek
giykamsefdifinyieaymtmk

Sequence, based on observed residues (ATOM records): (download)

>d1lk3b_ a.26.1.3 (B:) Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) {Human (Homo sapiens)}
nmlrdlrdafsrvktffqmkdqldnlllkeslledfkgylgcqalsemiqfyleevmpqa
enqdpdikahvnslgenlktlrlrlrrchrflpcekskaveqvknafnklqekgiykams
efdifinyieaymtmk

SCOP Domain Coordinates for d1lk3b_:

Click to download the PDB-style file with coordinates for d1lk3b_.
(The format of our PDB-style files is described here.)

Timeline for d1lk3b_: