SCOP 1.75: Domain d1l7il2: 1l7i L:108-214

Lineage for d1l7il2 (1l7i L:108-214)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (23 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (5 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (132 PDB entries)
   SQ NA # humanized antibody
   Uniprot P01834 # KAC_HUMAN Ig kappa chain C region
   SQ P01834 # KAC_HUMAN Ig kappa chain C region.
   SQ NA # engineered antibody
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d1l7il2: 1l7i L:108-214 [73659]
   Other proteins in same PDB: d1l7ih1, d1l7ih2, d1l7il1
   part of humanized anti-ERBb2 Fab 2C4
   complexed with so4

Details for d1l7il2

PDB Entry: 1l7i, 1.8 Å

PDB Description: Crystal Structure of the anti-ErbB2 Fab2C4

PDB Compounds: (L:) chimera of Fab2C4: "humanized" murine monoclonal antibody

SCOP Domain Sequences for d1l7il2:

Sequence; same for both SEQRES and ATOM records:

>d1l7il2 b.1.1.2 (L:108-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d1l7il2:

• d1l7il2 first appeared in SCOP 1.61
  
• d1l7il2 appears in SCOP 1.73
  
• d1l7il2 appears in SCOPe 2.01
  
• d1l7il2 appears in the current release, SCOPe 2.08