SCOP 1.71: Domain d1l7il1: 1l7i L:1-107

Lineage for d1l7il1 (1l7i L:1-107)

1. Root: SCOP 1.71

2. Class b: All beta proteins [48724] (149 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (25 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (28 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (14 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Engineered (including hybrid species) [88533] (52 PDB entries)

8. Domain d1l7il1: 1l7i L:1-107 [73658]
   Other proteins in same PDB: d1l7ih1, d1l7ih2, d1l7il2
   part of humanized anti-ERBb2 Fab 2C4
   complexed with so4

Details for d1l7il1

PDB Entry: 1l7i, 1.8 Å

PDB Description: Crystal Structure of the anti-ErbB2 Fab2C4

SCOP Domain Sequences for d1l7il1:

Sequence; same for both SEQRES and ATOM records:

>d1l7il1 b.1.1.1 (L:1-107) Immunoglobulin light chain kappa variable domain, VL-kappa {Engineered (including hybrid species)}
diqmtqspsslsasvgdrvtitckasqdvsigvawyqqkpgkapklliysasyrytgvps
rfsgsgsgtdftltisslqpedfatyycqqyyiypytfgqgtkveik

Timeline for d1l7il1:

• d1l7il1 first appeared in SCOP 1.61
  
• d1l7il1 appears in SCOP 1.69
  
• d1l7il1 appears in SCOP 1.73
  
• d1l7il1 appears in the current release, SCOPe 2.08