SCOP 1.75: Domain d1l2ib_: 1l2i B:

Lineage for d1l2ib_ (1l2i B:)

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (1 family)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (33 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (29 PDB entries)
   Uniprot P03372 307-551

8. Domain d1l2ib_: 1l2i B: [73504]
   complexed with ccs, cl, etc

Details for d1l2ib_

PDB Entry: 1l2i, 1.95 Å

PDB Description: human estrogen receptor alpha ligand-binding domain in complex with (r,r)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol and a glucocorticoid receptor interacting protein 1 nr box ii peptide

PDB Compounds: (B:) Estrogen receptor

SCOP Domain Sequences for d1l2ib_:

Sequence, based on SEQRES records:

>d1l2ib_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitd
tlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydllleml
dah

Sequence, based on observed residues (ATOM records):

>d1l2ib_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvytkdhihrvldkitdtlihlmakagl
tlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydlllemldah

Timeline for d1l2ib_:

• d1l2ib_ first appeared in SCOP 1.61
  
• d1l2ib_ appears in SCOP 1.73
  
• d1l2ib_ appears in SCOPe 2.01
  
• d1l2ib_ appears in the current release, SCOPe 2.08