SCOP 1.63: Domain d1ke7a_: 1ke7 A:

Lineage for d1ke7a_ (1ke7 A:)

1. Root: SCOP 1.63

2. Class d: Alpha and beta proteins (a+b) [53931] (224 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (6 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.1: Serine/threonin kinases [56113] (21 proteins)

6. Protein Cyclin-dependent PK (CDK, different isozymes) [56114] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56115] (47 PDB entries)

8. Domain d1ke7a_: 1ke7 A: [72366]
   complexed with ls3

Details for d1ke7a_

PDB Entry: 1ke7, 2 Å

PDB Description: cyclin-dependent kinase 2 (cdk2) complexed with 3-{[(2,2-dioxido-1,3- dihydro-2-benzothien-5-yl)amino]methylene}-5-(1,3-oxazol-5-yl)-1,3- dihydro-2h-indol-2-one

SCOP Domain Sequences for d1ke7a_:

Sequence, based on SEQRES records:

>d1ke7a_ d.144.1.1 (A:) Cyclin-dependent PK (CDK, different isozymes) {Human (Homo sapiens)}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Sequence, based on observed residues (ATOM records):

>d1ke7a_ d.144.1.1 (A:) Cyclin-dependent PK (CDK, different isozymes) {Human (Homo sapiens)}
menfqkvekigegtygvvykarnkltgevvalkkirvpstaireisllkelnhpnivkll
dvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrd
lkpqnllintegaikladfglarafvvtlwyrapeillgckyystavdiwslgcifaemv
trralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvpplde
dgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d1ke7a_:

• d1ke7a_ first appeared in SCOP 1.61
  
• d1ke7a_ appears in SCOP 1.65
  
• d1ke7a_ appears in the current release, SCOPe 2.08