SCOP 1.73: Domain d1k3td1: 1k3t D:1-164,D:334-359

Lineage for d1k3td1 (1k3t D:1-164,D:334-359)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (22 proteins)
   family members also share a common alpha+beta fold in C-terminal domain

6. Protein Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) [51801] (18 species)

7. Species Trypanosoma cruzi [TaxId:5693] [75104] (3 PDB entries)

8. Domain d1k3td1: 1k3t D:1-164,D:334-359 [72028]
   Other proteins in same PDB: d1k3ta2, d1k3tb2, d1k3tc2, d1k3td2
   complexed with brz

Details for d1k3td1

PDB Entry: 1k3t, 1.95 Å

PDB Description: Structure of Glycosomal Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi Complexed with Chalepin, a Coumarin Derivative Inhibitor

PDB Compounds: (D:) glyceraldehyde-3-phosphate dehydrogenase

SCOP Domain Sequences for d1k3td1:

Sequence; same for both SEQRES and ATOM records:

>d1k3td1 c.2.1.3 (D:1-164,D:334-359) Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) {Trypanosoma cruzi [TaxId: 5693]}
mpikvgingfgrigrmvfqalcedgllgteidvvavvdmntdaeyfayqmrydtvhgkfk
yevtttksspsvakddtlvvnghrilcvkaqrnpadlpwgklgveyviestglftakaaa
eghlrggarkvvisapasggaktlvmgvnhheynpsehhvvsnaXdnewgyshrvvdlvr
hmaskdrsarl

Timeline for d1k3td1:

• d1k3td1 first appeared in SCOP 1.61
  
• d1k3td1 appears in SCOP 1.71
  
• d1k3td1 appears in SCOP 1.75
  
• d1k3td1 appears in the current release, SCOPe 2.08