SCOP 1.65: Domain d1k3tc1: 1k3t C:1-164,C:334-359

Lineage for d1k3tc1 (1k3t C:1-164,C:334-359)

1. Root: SCOP 1.65

2. Class c: Alpha and beta proteins (a/b) [51349] (121 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families)

5. Family c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (13 proteins)
   family members also share a common alpha+beta fold in C-terminal domain

6. Protein Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) [51801] (14 species)

7. Species Trypanosoma cruzi [TaxId:5693] [75104] (2 PDB entries)

8. Domain d1k3tc1: 1k3t C:1-164,C:334-359 [72026]
   Other proteins in same PDB: d1k3ta2, d1k3tb2, d1k3tc2, d1k3td2

Details for d1k3tc1

PDB Entry: 1k3t, 1.95 Å

PDB Description: Structure of Glycosomal Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi Complexed with Chalepin, a Coumarin Derivative Inhibitor

SCOP Domain Sequences for d1k3tc1:

Sequence; same for both SEQRES and ATOM records:

>d1k3tc1 c.2.1.3 (C:1-164,C:334-359) Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) {Trypanosoma cruzi}
mpikvgingfgrigrmvfqalcedgllgteidvvavvdmntdaeyfayqmrydtvhgkfk
yevtttksspsvakddtlvvnghrilcvkaqrnpadlpwgklgveyviestglftakaaa
eghlrggarkvvisapasggaktlvmgvnhheynpsehhvvsnaXdnewgyshrvvdlvr
hmaskdrsarl

Timeline for d1k3tc1:

• d1k3tc1 first appeared in SCOP 1.61
  
• d1k3tc1 appears in SCOP 1.63
  
• d1k3tc1 appears in SCOP 1.67
  
• d1k3tc1 appears in the current release, SCOPe 2.08