SCOP 1.75: Domain d1isna2: 1isn A:215-340

Lineage for d1isna2 (1isn A:215-340)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.55: PH domain-like barrel [50728] (2 superfamilies)
   barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix

4. Superfamily b.55.1: PH domain-like [50729] (13 families)

5. Family b.55.1.5: Third domain of FERM [50776] (8 proteins)

6. Protein Merlin [69294] (2 species)
   the neurofibromatosis 2 tumor suppressor protein

7. Species Mouse (Mus musculus) [TaxId:10090] [74995] (1 PDB entry)

8. Domain d1isna2: 1isn A:215-340 [71401]
   Other proteins in same PDB: d1isna1, d1isna3

Details for d1isna2

PDB Entry: 1isn, 2.9 Å

PDB Description: Crystal structure of merlin FERM domain

PDB Compounds: (A:) merlin

SCOP Domain Sequences for d1isna2:

Sequence; same for both SEQRES and ATOM records:

>d1isna2 b.55.1.5 (A:215-340) Merlin {Mouse (Mus musculus) [TaxId: 10090]}
emygvnyftirnkkgtelllgvdalglhiydpenrltpkisfpwneirnisysdkeftik
pldkkidvfkfnssklrvnklilqlcignhdlfmrrrkadslevqqmkaqareekarkqm
erqrla

Timeline for d1isna2:

• d1isna2 first appeared in SCOP 1.61
  
• d1isna2 appears in SCOP 1.73
  
• d1isna2 appears in SCOPe 2.01
  
• d1isna2 appears in the current release, SCOPe 2.08