SCOPe 2.08: Domain d1gt8c2: 1gt8 C:533-844

Lineage for d1gt8c2 (1gt8 C:533-844)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)

6. Protein Dihydropyrimidine dehydrogenase, domain 4 [51410] (1 species)

7. Species Pig (Sus scrofa) [TaxId:9823] [51411] (9 PDB entries)

8. Domain d1gt8c2: 1gt8 C:533-844 [70429]
   Other proteins in same PDB: d1gt8a1, d1gt8a3, d1gt8a4, d1gt8a5, d1gt8b1, d1gt8b3, d1gt8b4, d1gt8b5, d1gt8c1, d1gt8c3, d1gt8c4, d1gt8c5, d1gt8d1, d1gt8d3, d1gt8d4, d1gt8d5
   complexed with fad, fmn, ndp, sf4, uaa
   has additional subdomain(s) that are not in the common domain
   has additional insertions and/or extensions that are not grouped together

Details for d1gt8c2

PDB Entry: 1gt8, 3.3 Å

PDB Description: dihydropyrimidine dehydrogenase (dpd) from pig, ternary complex with nadph and uracil-4-acetic acid

PDB Compounds: (C:) dihydropyrimidine dehydrogenase

SCOPe Domain Sequences for d1gt8c2:

Sequence, based on SEQRES records:

>d1gt8c2 c.1.4.1 (C:533-844) Dihydropyrimidine dehydrogenase, domain 4 {Pig (Sus scrofa) [TaxId: 9823]}
isvemaglkfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivr
gttsgpmygpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwme
lsrkaeasgadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltp
nvtdivsiaraakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairp
ialravttiaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyct
glkallylksie

Sequence, based on observed residues (ATOM records):

>d1gt8c2 c.1.4.1 (C:533-844) Dihydropyrimidine dehydrogenase, domain 4 {Pig (Sus scrofa) [TaxId: 9823]}
isvemaglkfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivr
gttsgpmygpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwme
lsrkaeasgadalelnlscplacgqdpelvrnicrwvrqavqipffakltpnvtdivsia
raakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtti
aralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylk
sie

Timeline for d1gt8c2:

• d1gt8c2 first appeared in SCOP 1.61
  
• d1gt8c2 appears in SCOPe 2.07