Lineage for Protein: E1-beta subunit of pyruvate dehydrogenase, Pyr module

  1. Root: SCOP 1.73
  2. 681097Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
  3. 694610Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 694611Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 694773Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (4 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
  6. 694813Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species)

Species:

  1. 694814Archaeon Pyrobaculum aerophilum [TaxId:13773] [69473] (1 PDB entry)
  2. 694816Human (Homo sapiens) [TaxId:9606] [89653] (2 PDB entries)
    1. Domains for 1ni4:
      1. 694819Domain d1ni4b1: 1ni4 B:0-191 [85729]
        Other proteins in same PDB: d1ni4a_, d1ni4b2, d1ni4c_, d1ni4d2
      2. 694820Domain d1ni4d1: 1ni4 D:0-191 [85732]
        Other proteins in same PDB: d1ni4a_, d1ni4b2, d1ni4c_, d1ni4d2
        complexed with k, mg, mse, tpp; mutant
    2. Domains for 2ozl:
      1. 694817Domain d2ozlb1: 2ozl B:0-191 [139447]
        Other proteins in same PDB: d2ozlb2, d2ozld2
        automatically matched to d1ni4b1
        complexed with k, mg, tpp; mutant
      2. 694818Domain d2ozld1: 2ozl D:0-191 [139449]
        Other proteins in same PDB: d2ozlb2, d2ozld2
        automatically matched to d1ni4b1
        complexed with k, mg, tpp; mutant

More info for Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

Timeline for Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module: