SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Protein: Cellobiohydrolase I (cellulase, Endoglucanase I, CBH1)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2042196Fold b.29: Concanavalin A-like lectins/glucanases [49898] (1 superfamily)
    sandwich; 12-14 strands in 2 sheets; complex topology
  4. 2042197Superfamily b.29.1: Concanavalin A-like lectins/glucanases [49899] (26 families) (S)
  5. 2043561Family b.29.1.10: Glycosyl hydrolase family 7 catalytic core [49971] (2 protein domains)
    contains many insertions in the common fold
    automatically mapped to Pfam PF00840
  6. 2043562Protein Cellobiohydrolase I (cellulase, Endoglucanase I, CBH1) [68900] (7 species)

Species:

  1. 2043563Basidomycetes fungus (Phanerochaete chrysosporium), Cel7d [TaxId:5306] [69239] (2 PDB entries)
    1. Domain for 1gpi:
    2. Domain for 1h46:
  2. 2043566Fungus (Fusarium oxysporum) [TaxId:5507] [49976] (4 PDB entries)
    1. Domains for 1ovw:
      1. 2043575Domain d1ovwa_: 1ovw A: [24300]
        complexed with dp5, nag
      2. 2043576Domain d1ovwb_: 1ovw B: [24301]
        complexed with dp5, nag
      3. 2043577Domain d1ovwc_: 1ovw C: [24302]
        complexed with dp5, nag
      4. 2043578Domain d1ovwd_: 1ovw D: [24303]
        complexed with dp5, nag
    2. Domains for 2ovw:
      1. 2043571Domain d2ovwa_: 2ovw A: [24296]
        complexed with cbi, nag
      2. 2043572Domain d2ovwb_: 2ovw B: [24297]
        complexed with cbi, nag
      3. 2043573Domain d2ovwc_: 2ovw C: [24298]
        complexed with cbi, nag
      4. 2043574Domain d2ovwd_: 2ovw D: [24299]
        complexed with cbi, nag
    3. Domains for 3ovw:
      1. 2043567Domain d3ovwa_: 3ovw A: [24292]
        complexed with nag
      2. 2043568Domain d3ovwb_: 3ovw B: [24293]
        complexed with nag
    4. Domains for 4ovw:
      1. 2043569Domain d4ovwa_: 4ovw A: [24294]
        complexed with in1, nag
      2. 2043570Domain d4ovwb_: 4ovw B: [24295]
        complexed with in1, nag
  3. 2043579Humicola insolens, Cel7b [TaxId:34413] [49977] (6 PDB entries)
    1. Domain for 1a39:
    2. Domain for 1dym:
    3. Domain for 1oji:
    4. Domains for 1ojj:
      1. 2043580Domain d1ojja_: 1ojj A: [93130]
        complexed with nag; mutant
      2. 2043581Domain d1ojjb_: 1ojj B: [93131]
        complexed with nag; mutant
    5. Domains for 1ojk:
      1. 2043582Domain d1ojka_: 1ojk A: [93132]
        complexed with gol, nag; mutant
      2. 2043583Domain d1ojkb_: 1ojk B: [93133]
        complexed with gol, nag; mutant
    6. Domains for 2a39:
      1. 2043587Domain d2a39a_: 2a39 A: [24306]
        complexed with nag
      2. 2043588Domain d2a39b_: 2a39 B: [24307]
        complexed with nag
  4. 2043589Talaromyces emersonii [TaxId:68825] [117136] (1 PDB entry)
    Uniprot Q8TFL9
  5. 2043591Trichoderma reesei, Cel7A [TaxId:51453] [68898] (20 PDB entries)
    1. Domains for 1cel:
      1. 2043598Domain d1cela_: 1cel A: [24280]
        complexed with bgc, ca, glc, ibz, nag
      2. 2043599Domain d1celb_: 1cel B: [24281]
        complexed with bgc, ca, glc, ibz, nag
    2. Domain for 1dy4:
    3. Domain for 1egn:
    4. Domain for 1q2b:
    5. Domains for 1q2e:
      1. 2043602Domain d1q2ea_: 1q2e A: [95625]
        complexed with ca, nag
      2. 2043603Domain d1q2eb_: 1q2e B: [95626]
        complexed with ca, nag
    6. Domains for 2cel:
      1. 2043607Domain d2cela_: 2cel A: [24285]
        complexed with ca, nag; mutant
      2. 2043608Domain d2celb_: 2cel B: [24286]
        complexed with ca, nag; mutant
    7. Domain for 3cel:
    8. Domain for 4c4c:
    9. Domain for 4c4d:
    10. Domains for 4cel:
      1. 2043612Domain d4cela_: 4cel A: [24288]
        complexed with ca, nag; mutant
      2. 2043613Domain d4celb_: 4cel B: [24289]
        complexed with ca, nag; mutant
    11. Domain for 4d5i:
    12. Domain for 4d5j:
    13. Domain for 4d5o:
    14. Domain for 4d5p:
    15. Domain for 4d5v:
    16. Domain for 4p1j:
    17. Domain for 4uwt:
    18. Domain for 5cel:
    19. Domain for 6cel:
    20. Domain for 7cel:
  6. 2043616Trichoderma reesei, Endoglucanase I [TaxId:51453] [68899] (1 PDB entry)
  7. 2284571Hypocrea jecorina [TaxId:431241] [327872] (1 PDB entry)

More info for Protein Cellobiohydrolase I (cellulase, Endoglucanase I, CBH1) from b.29.1.10: Glycosyl hydrolase family 7 catalytic core

Timeline for Protein Cellobiohydrolase I (cellulase, Endoglucanase I, CBH1) from b.29.1.10: Glycosyl hydrolase family 7 catalytic core: