SCOPe 2.06: Domain d1jleb_: 1jle B:

Lineage for d1jleb_ (1jle B:)

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (4 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (172 PDB entries)
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

8. Domain d1jleb_: 1jle B: [66844]
   Other proteins in same PDB: d1jlea1
   mutant

Details for d1jleb_

PDB Entry: 1jle, 2.8 Å

PDB Description: crystal structure of y188c mutant hiv-1 reverse transcriptase

PDB Compounds: (B:) hiv-1 rt, b-chain

SCOPe Domain Sequences for d1jleb_:

Sequence, based on SEQRES records:

>d1jleb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfai
kkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvplded
frkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqy
mddlcvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqp
ivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelel
aenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtn
dvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplv
klwyqlekepi

Sequence, based on observed residues (ATOM records):

>d1jleb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfai
kkkdstkwrklvdfrelnkrtqdfqlgiphpaglkkkksvtvldvgdayfsvpldedfrk
ytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymdd
lcvgsdleigqhrtkieelrqhllrwelhpdkwtvqpivlpekdswtvndiqklvgklnw
asqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdli
aeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgkt
pkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepi

Timeline for d1jleb_:

• d1jleb_ first appeared in SCOP 1.59, called d1jleb1
  
• d1jleb_ appears in SCOPe 2.05
  
• d1jleb_ appears in SCOPe 2.07
  
• d1jleb_ appears in the current release, SCOPe 2.08