SCOP 1.73: Domain d1iase_: 1ias E:

Lineage for d1iase_ (1ias E:)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Type I TGF-beta receptor R4 [56144] (1 species)
   TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

7. Species Human (Homo sapiens) [TaxId:9606] [56145] (4 PDB entries)

8. Domain d1iase_: 1ias E: [66104]
   complexed with so4

Details for d1iase_

PDB Entry: 1ias, 2.9 Å

PDB Description: cytoplasmic domain of unphosphorylated type i tgf-beta receptor crystallized without fkbp12

PDB Compounds: (E:) tgf-beta receptor type I

SCOP Domain Sequences for d1iase_:

Sequence; same for both SEQRES and ATOM records:

>d1iase_ d.144.1.7 (E:) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
isegttlkdliydmttsgsgsglpllvqrtiartivlqesigkgrfgevwrgkwrgeeva
vkifssreerswfreaeiyqtvmlrhenilgfiaadnkdngtwtqlwlvsdyhehgslfd
ylnrytvtvegmiklalstasglahlhmeivgtqgkpaiahrdlksknilvkkngtccia
dlglavrhdsatdtidiapnhrvgtkrymapevlddsinmkhfesfkradiyamglvfwe
iarrcsiggihedyqlpyydlvpsdpsveemrkvvceqklrpnipnrwqscealrvmaki
mrecwyangaarltalrikktlsqlsqqeg

Timeline for d1iase_:

• d1iase_ first appeared in SCOP 1.59
  
• d1iase_ appears in SCOP 1.71
  
• d1iase_ appears in SCOP 1.75
  
• d1iase_ appears in the current release, SCOPe 2.08