SCOPe 2.02: Domain d1iasb_: 1ias B:

Lineage for d1iasb_ (1ias B:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Type I TGF-beta receptor R4 [56144] (1 species)
   TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

7. Species Human (Homo sapiens) [TaxId:9606] [56145] (9 PDB entries)
   Uniprot P36897 200-500 ! Uniprot P36897 201-503

8. Domain d1iasb_: 1ias B: [66101]
   complexed with so4

Details for d1iasb_

PDB Entry: 1ias, 2.9 Å

PDB Description: cytoplasmic domain of unphosphorylated type i tgf-beta receptor crystallized without fkbp12

PDB Compounds: (B:) tgf-beta receptor type I

SCOPe Domain Sequences for d1iasb_:

Sequence, based on SEQRES records:

>d1iasb_ d.144.1.7 (B:) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
isegttlkdliydmttsgsgsglpllvqrtiartivlqesigkgrfgevwrgkwrgeeva
vkifssreerswfreaeiyqtvmlrhenilgfiaadnkdngtwtqlwlvsdyhehgslfd
ylnrytvtvegmiklalstasglahlhmeivgtqgkpaiahrdlksknilvkkngtccia
dlglavrhdsatdtidiapnhrvgtkrymapevlddsinmkhfesfkradiyamglvfwe
iarrcsiggihedyqlpyydlvpsdpsveemrkvvceqklrpnipnrwqscealrvmaki
mrecwyangaarltalrikktlsqlsqqegi

Sequence, based on observed residues (ATOM records):

>d1iasb_ d.144.1.7 (B:) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
isegttlkdliydmttsgsgsglpllvqrtiartivlqesigkgrfgevwrgkwrgeeva
vkifssreerswfreaeiyqtvmlrhenilgfiaadnkdngtwtqlwlvsdyhehgslfd
ylnrytvtvegmiklalstasglahlhmeigkpaiahrdlksknilvkkngtcciadlgl
avrhdsatdtidihrvgtkrymapevlddsinmkhfesfkradiyamglvfweiarrcsi
ggihedyqlpyydlvpsdpsveemrkvvceqklrpnipnrwqscealrvmakimrecwya
ngaarltalrikktlsqlsqqegi

Timeline for d1iasb_:

• d1iasb_ first appeared in SCOP 1.59
  
• d1iasb_ appears in SCOPe 2.01
  
• d1iasb_ appears in SCOPe 2.03
  
• d1iasb_ appears in the current release, SCOPe 2.08