SCOPe 2.01: Domain d1i3gl_: 1i3g L:

Lineage for d1i3gl_ (1i3g L:)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88531] (184 PDB entries)
   Uniprot P01645 1-106 # 95% sequense identity; KV5L_MOUSE Ig kappa chain V-V region HP 93G7 ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! SQ NA # humanized antibody ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01642 21-115 # ! KV5I_MOUSE Ig kappa chain V-V region L7 precursor

8. Domain d1i3gl_: 1i3g L: [66019]
   Other proteins in same PDB: d1i3gh_
   part of anti-ampicillin scFv
   complexed with mpd

Details for d1i3gl_

PDB Entry: 1i3g, 2.44 Å

PDB Description: crystal structure of an ampicillin single chain fv, form 1, free

PDB Compounds: (L:) antibody fv fragment

SCOPe Domain Sequences for d1i3gl_:

Sequence; same for both SEQRES and ATOM records:

>d1i3gl_ b.1.1.1 (L:) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 4 [TaxId: 10090]}
divltqshkfmstsvgdrvsitckasqdvgtavawyqqkpgqspklliywastrhtgvpd
rftgsgsgtdftltisnvqsedladyfcqqyssypltfgagtklel

Timeline for d1i3gl_:

• d1i3gl_ first appeared in SCOP 1.59
  
• d1i3gl_ appears in SCOP 1.75
  
• d1i3gl_ appears in SCOPe 2.02
  
• d1i3gl_ appears in the current release, SCOPe 2.08