SCOP 1.75: Domain d1fl6a1: 1fl6 A:1-107

Lineage for d1fl6a1 (1fl6 A:1-107)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (32 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1.1 [TaxId:10090] [88524] (127 PDB entries)
   Uniprot P01631 #KV2G_MOUSE Ig kappa chain V-II region 26-10; 79% sequence identity
   Uniprot P06310 # KV2F_HUMAN IG KAPPA CHAIN V-II REGION RPMI 6410 PRECURSOR
   Uniprot P03976 # KV2E_MOUSE (P03976) Ig kappa chain V-II region 17S29.1
   Uniprot P01642 21-115 #
   KV2G_MOUSE IG KAPPA CHAIN V-II REGION 26-10
   Uniprot P01631 #KV2G_MOUSE Ig kappa chain V-II region 26-10; 79% sequence identity ! Uniprot P06310 # KV2F_HUMAN IG KAPPA CHAIN V-II REGION RPMI 6410 PRECURSOR ! Uniprot P03976 # KV2E_MOUSE (P03976) Ig kappa chain V-II region 17S29.1 ! Uniprot P01642 21-115 # ! KV2G_MOUSE IG KAPPA CHAIN V-II REGION 26-10

8. Domain d1fl6a1: 1fl6 A:1-107 [65023]
   Other proteins in same PDB: d1fl6a2, d1fl6b1, d1fl6b2, d1fl6h1, d1fl6h2, d1fl6l2
   part of humanized catalytic Fab 28b4 with a sulfide oxidase activity
   complexed with aah; mutant

Details for d1fl6a1

PDB Entry: 1fl6, 2.8 Å

PDB Description: the hapten complexed germline precursor to sulfide oxidase catalytic antibody 28b4

PDB Compounds: (A:) antibody germline precursor to 28b4

SCOP Domain Sequences for d1fl6a1:

Sequence; same for both SEQRES and ATOM records:

>d1fl6a1 b.1.1.1 (A:1-107) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 1.1 [TaxId: 10090]}
elvmtqtplslpvslgdqasiscrssqsivhsngntylewylqkpgqspklliykvsnrf
sgvpdrfsgsgsgtdftlkisrveaedlgvyycfqgshvprtfgggtkleik

Timeline for d1fl6a1:

• d1fl6a1 first appeared in SCOP 1.59
  
• d1fl6a1 appears in SCOP 1.73
  
• d1fl6a1 appears in SCOPe 2.01
  
• d1fl6a1 appears in the current release, SCOPe 2.08