SCOP 1.69: Domain d1fl5b1: 1fl5 B:1-113

Lineage for d1fl5b1 (1fl5 B:1-113)

1. Root: SCOP 1.69

2. Class b: All beta proteins [48724] (144 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (23 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (27 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (20 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1 [TaxId:10090] [88548] (42 PDB entries)

8. Domain d1fl5b1: 1fl5 B:1-113 [65017]
   Other proteins in same PDB: d1fl5a1, d1fl5a2, d1fl5b2, d1fl5h2, d1fl5l1, d1fl5l2
   part of humanized catalytic Fab 28b4 with a sulfide oxidase activity

Details for d1fl5b1

PDB Entry: 1fl5, 2.1 Å

PDB Description: the unliganded germline precursor to the sulfide oxidase catalytic antibody 28b4.

SCOP Domain Sequences for d1fl5b1:

Sequence; same for both SEQRES and ATOM records:

>d1fl5b1 b.1.1.1 (B:1-113) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 1}
qvqlvesggglvqpggslrlscatsgftftdyymswvrqppgkalewlgfirnkangytt
eysasvkgrftisrdnsqsilylqmntlraedsatyycardgsyamdywgqgtsvtvss

Timeline for d1fl5b1:

• d1fl5b1 first appeared in SCOP 1.59
  
• d1fl5b1 appears in SCOP 1.67
  
• d1fl5b1 appears in SCOP 1.71
  
• d1fl5b1 appears in the current release, SCOPe 2.08