SCOPe 2.03: Domain d1ea6a2: 1ea6 A:27-231

Lineage for d1ea6a2 (1ea6 A:27-231)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.2: DNA gyrase/MutL, N-terminal domain [55879] (7 proteins)

6. Protein DNA mismatch repair protein PMS2 [69800] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [69801] (3 PDB entries)

8. Domain d1ea6a2: 1ea6 A:27-231 [64872]
   Other proteins in same PDB: d1ea6a1, d1ea6b1
   protein/DNA complex; complexed with adp, mg

Details for d1ea6a2

PDB Entry: 1ea6, 2.7 Å

PDB Description: n-terminal 40kda fragment of nhpms2 complexed with adp

PDB Compounds: (A:) pms1 protein homolog 2

SCOPe Domain Sequences for d1ea6a2:

Sequence, based on SEQRES records:

>d1ea6a2 d.122.1.2 (A:27-231) DNA mismatch repair protein PMS2 {Human (Homo sapiens) [TaxId: 9606]}
csgqvvlslstavkelvensldagatnidlklkdygvdlievsdngcgveeenfegltlk
hhtskiqefadltqvetfgfrgealsslcalsdvtistchasakvgtrlmfdhngkiiqk
tpyprprgttvsvqqlfstlpvrhkefqrnikkeyakmvqvlhayciisagirvsctnql
gqgkrqpvvctggspsikenigsvf

Sequence, based on observed residues (ATOM records):

>d1ea6a2 d.122.1.2 (A:27-231) DNA mismatch repair protein PMS2 {Human (Homo sapiens) [TaxId: 9606]}
csgqvvlslstavkelvensldagatnidlklkdygvdlievsdngcgveeenfegltle
alsslcalsdvtistchasakvgtrlmfdhngkiiqktpyprprgttvsvqqlfstlpvr
hkefqrnikkeyakmvqvlhayciisagirvsctnqlgqgkrqpvvctggspsikenigs
vf

Timeline for d1ea6a2:

• d1ea6a2 first appeared in SCOP 1.59
  
• d1ea6a2 appears in SCOPe 2.02
  
• d1ea6a2 appears in SCOPe 2.04
  
• d1ea6a2 appears in the current release, SCOPe 2.08