SCOP 1.75: Family c.31.1.5: Sir2 family of transcriptional regulators

Lineage for Family c.31.1.5: Sir2 family of transcriptional regulators

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (6 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (7 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

Proteins:

1. AF0112, Sir2 homolog (Sir2-AF2) [82380] (1 species)

   • Species Archaeon Archaeoglobus fulgidus [TaxId:2234] [82381] (3 PDB entries)

2. AF1676, Sir2 homolog (Sir2-AF1?) [63985] (1 species)

   • Species Archaeon Archaeoglobus fulgidus [TaxId:2234] [63986] (6 PDB entries)

3. Hst2 [102294] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [102295] (5 PDB entries)
     Uniprot P53686 1-293

4. NAD-dependent deacetylase CobB [102292] (1 species)

   • Species Escherichia coli [TaxId:562] [102293] (1 PDB entry)

5. NAD-dependent deacetylase NpdA [142126] (1 species)

   • Species Thermotoga maritima [TaxId:2336] [142127] (10 PDB entries)
     Uniprot Q9WYW0 1-245

6. NAD-dependent deacetylase sirtuin-5 [142128] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [142129] (2 PDB entries)
     Uniprot Q9NXA8 36-302

7. Sirt2 histone deacetylase [63987] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [63988] (1 PDB entry)

More info for Family c.31.1.5: Sir2 family of transcriptional regulators

Timeline for Family c.31.1.5: Sir2 family of transcriptional regulators:

• Family c.31.1.5: Sir2 family of transcriptional regulators first appeared in SCOP 1.57
  
• Family c.31.1.5: Sir2 family of transcriptional regulators appears in SCOP 1.73
  
• Family c.31.1.5: Sir2 family of transcriptional regulators appears in SCOPe 2.01
  
• Family c.31.1.5: Sir2 family of transcriptional regulators appears in the current release, SCOPe 2.08