SCOP 1.75: Species: Leishmania major [TaxId: 5664]

Lineage for Species: Leishmania major [TaxId: 5664]

Root: SCOP 1.75
Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein Dihydropteridin reductase (pteridine reductase) [51769] (6 species)
Species Leishmania major [TaxId:5664] [63926] (10 PDB entries)
Uniprot Q01782

PDB entries in Species: Leishmania major [TaxId: 5664]:

Domain(s) for 1e7w:
1. Domain d1e7wa_: 1e7w A: [59373]
2. Domain d1e7wb_: 1e7w B: [59374]
  complexed with edo, mtx, ndp
Domain(s) for 1e92:
1. Domain d1e92a_: 1e92 A: [64798]
2. Domain d1e92b_: 1e92 B: [64799]
3. Domain d1e92c_: 1e92 C: [64800]
4. Domain d1e92d_: 1e92 D: [64801]
  complexed with edo, hbi, nap
Domain(s) for 1w0c:
1. Domain d1w0ca_: 1w0c A: [114052]
2. Domain d1w0cb_: 1w0c B: [114053]
3. Domain d1w0cc_: 1w0c C: [114054]
4. Domain d1w0cd_: 1w0c D: [114055]
5. Domain d1w0ce_: 1w0c E: [114056]
6. Domain d1w0cf_: 1w0c F: [114057]
7. Domain d1w0cg_: 1w0c G: [114058]
8. Domain d1w0ch_: 1w0c H: [114059]
  complexed with nap, taq
Domain(s) for 2bf7:
1. Domain d2bf7a1: 2bf7 A:6-288 [128407]
  automatically matched to d1e7wa_
  complexed with edo, hbi, nap
2. Domain d2bf7b1: 2bf7 B:6-288 [128408]
  automatically matched to d1e7wa_
  complexed with edo, hbi, nap
3. Domain d2bf7c1: 2bf7 C:6-288 [128409]
  automatically matched to d1e7wa_
  complexed with edo, hbi, nap
4. Domain d2bf7d1: 2bf7 D:6-288 [128410]
  automatically matched to d1e7wa_
  complexed with edo, hbi, nap
Domain(s) for 2bfa:
1. Domain d2bfaa1: 2bfa A:6-288 [128413]
  automatically matched to d1e7wa_
  complexed with cb3, edo, ndp
2. Domain d2bfab1: 2bfa B:6-288 [128414]
  automatically matched to d1e7wa_
  complexed with cb3, edo, ndp
3. Domain d2bfac1: 2bfa C:6-288 [128415]
  automatically matched to d1e7wa_
  complexed with cb3, edo, ndp
4. Domain d2bfad1: 2bfa D:6-288 [128416]
  automatically matched to d1e7wa_
  complexed with cb3, edo, ndp
Domain(s) for 2bfm:
1. Domain d2bfma1: 2bfm A:6-288 [128439]
  automatically matched to d1e7wa_
  complexed with ndp, top
2. Domain d2bfmb1: 2bfm B:6-288 [128440]
  automatically matched to d1e7wa_
  complexed with ndp, top
3. Domain d2bfmc1: 2bfm C:6-288 [128441]
  automatically matched to d1e7wa_
  complexed with ndp, top
4. Domain d2bfmd1: 2bfm D:6-288 [128442]
  automatically matched to d1e7wa_
  complexed with ndp, top
Domain(s) for 2bfo:
1. Domain d2bfoa1: 2bfo A:6-288 [128444]
  automatically matched to d1e7wa_
  complexed with edo, ndp
2. Domain d2bfob1: 2bfo B:6-288 [128445]
  automatically matched to d1e7wa_
  complexed with edo, ndp
3. Domain d2bfoc1: 2bfo C:6-288 [128446]
  automatically matched to d1e7wa_
  complexed with edo, ndp
4. Domain d2bfod1: 2bfo D:6-288 [128447]
  automatically matched to d1e7wa_
  complexed with edo, ndp
Domain(s) for 2bfp:
1. Domain d2bfpa1: 2bfp A:6-288 [128448]
  automatically matched to d1e7wa_
  complexed with edo, h4b, nap
2. Domain d2bfpb1: 2bfp B:6-288 [128449]
  automatically matched to d1e7wa_
  complexed with edo, h4b, nap
3. Domain d2bfpc1: 2bfp C:6-288 [128450]
  automatically matched to d1e7wa_
  complexed with edo, h4b, nap
4. Domain d2bfpd1: 2bfp D:6-288 [128451]
  automatically matched to d1e7wa_
  complexed with edo, h4b, nap
Domain(s) for 2p8k:
1. Domain d2p8ka1: 2p8k A:5-288 [149305]
  automatically matched to d1e7wa_
  complexed with dyp, nap
2. Domain d2p8kb1: 2p8k B:5-288 [149306]
  automatically matched to d1e7wa_
  complexed with dyp, nap
3. Domain d2p8kc1: 2p8k C:6-288 [149307]
  automatically matched to d1e7wa_
  complexed with dyp, nap
4. Domain d2p8kd1: 2p8k D:5-288 [149308]
  automatically matched to d1e7wa_
  complexed with dyp, nap
5. Domain d2p8ke1: 2p8k E:6-288 [149309]
  automatically matched to d1e7wa_
  complexed with dyp, nap
6. Domain d2p8kf1: 2p8k F:5-288 [149310]
  automatically matched to d1e7wa_
  complexed with dyp, nap
7. Domain d2p8kg1: 2p8k G:6-288 [149311]
  automatically matched to d1e7wa_
  complexed with dyp, nap
8. Domain d2p8kh1: 2p8k H:5-288 [149312]
  automatically matched to d1e7wa_
  complexed with dyp, nap
Domain(s) for 2qhx:
1. Domain d2qhxa1: 2qhx A:5-288 [150796]
  automatically matched to d1e7wa_
  complexed with fe1, iod, nap
2. Domain d2qhxb1: 2qhx B:5-288 [150797]
  automatically matched to d1e7wa_
  complexed with fe1, iod, nap
3. Domain d2qhxc1: 2qhx C:6-288 [150798]
  automatically matched to d1e7wa_
  complexed with fe1, iod, nap
4. Domain d2qhxd1: 2qhx D:5-288 [150799]
  automatically matched to d1e7wa_
  complexed with fe1, iod, nap

More info for Species Leishmania major [TaxId:5664] from c.2.1.2 Dihydropteridin reductase (pteridine reductase)

Timeline for Species Leishmania major [TaxId:5664] from c.2.1.2 Dihydropteridin reductase (pteridine reductase):

Species Leishmania major [TaxId:5664] from c.2.1.2 Dihydropteridin reductase (pteridine reductase) first appeared in SCOP 1.57
Species Leishmania major [TaxId:5664] from c.2.1.2 Dihydropteridin reductase (pteridine reductase) appears in SCOP 1.73
Species Leishmania major [TaxId:5664] from c.2.1.2 Dihydropteridin reductase (pteridine reductase) appears in SCOPe 2.01
Species Leishmania major [TaxId:5664] from c.2.1.2 Dihydropteridin reductase (pteridine reductase) appears in the current release, SCOPe 2.08