Class d: Alpha and beta proteins (a+b) [53931] (334 folds) |
Fold d.185: LuxS/MPP-like metallohydrolase [63410] (1 superfamily) core: beta-alpha-beta(2)-alpha(2); 2 layers: alpha/beta |
Superfamily d.185.1: LuxS/MPP-like metallohydrolase [63411] (2 families) Share the same "active site motif" HxxEH located in the first core helix, but differ in one of the zinc-binding residues |
d.185.1.1: MPP-like [63412] (6 proteins) Common fold elaborated with many additional structures; duplication: each family member consists of two similar domains of beta(2)-alpha(2)-beta(2)-alpha(5)-beta structure, but only the N-terminal domain of MPP beta chain binds the catalytic metal |
d.185.1.2: Autoinducer-2 production protein LuxS [64294] (1 protein) contains additional N-terminal strand; possible relationships to the putative editing domain of ThrRS (d.67.1) |
Timeline for Superfamily d.185.1: LuxS/MPP-like metallohydrolase: