SCOPe 2.02: Family a.4.5.28: MarR-like transcriptional regulators

Lineage for Family a.4.5.28: MarR-like transcriptional regulators

1. Root: SCOPe 2.02

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (14 superfamilies)
   core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down

4. Superfamily a.4.5: "Winged helix" DNA-binding domain [46785] (85 families)
   contains a small beta-sheet (wing)

5. Family a.4.5.28: MarR-like transcriptional regulators [63379] (20 proteins)
   The N- and C-terminal helical extensions to the common fold form the dimer interface

Proteins:

1. Hypothetical protein PH1061 [101014] (1 species)

   • Species Pyrococcus horikoshii [TaxId:53953] [101015] (1 PDB entry)

2. MexR repressor [81686] (1 species)

   • Species Pseudomonas aeruginosa [TaxId:287] [81687] (3 PDB entries)

3. Multiple antibiotic resistance repressor, MarR [68970] (1 species)

   • Species Escherichia coli [TaxId:562] [68971] (1 PDB entry)

4. Organic hydroperoxide resistance transcriptional regulator OhrR [140247] (1 species)

   • Species Bacillus subtilis [TaxId:1423] [140248] (2 PDB entries)
     Uniprot O34777 8-144

5. Pleiotropic regulator of virulence genes, SarA [48292] (1 species)
   closely related to SarR but adopts a different fold; possible experimental artifact?

   • Species Staphylococcus aureus [TaxId:1280] [48293] (3 PDB entries)

6. Probable transcriptional regulator PA3067 [140243] (1 species)

   • Species Pseudomonas aeruginosa [TaxId:287] [140244] (1 PDB entry)
     Uniprot Q9HZE1 2-146

7. Probable transcriptional regulator PA4135 [140245] (1 species)

   • Species Pseudomonas aeruginosa [TaxId:287] [140246] (1 PDB entry)
     Uniprot Q9HWP6 5-140

8. Protease production regulatory protein Hpr [140251] (1 species)

   • Species Bacillus subtilis [TaxId:1423] [140252] (1 PDB entry)
     Uniprot P11065 6-167

9. Putative transcriptional regulator TM0816 [140241] (1 species)

   • Species Thermotoga maritima [TaxId:2336] [140242] (1 PDB entry)
     Uniprot Q9WZS3 1-140

10. Putative transcriptional regulator YusO [101012] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [101013] (1 PDB entry)

11. Staphylococcal accessory regulator A homolog, SarR [63472] (1 species)

    • Species Staphylococcus aureus [TaxId:1280] [63473] (1 PDB entry)

12. Staphylococcal accessory regulator A homolog, SarS [88977] (1 species)
    duplication: tandem repeat of two SarR-like domains assembled together as in the SarR dimer

    • Species Staphylococcus aureus [TaxId:1280] [88978] (1 PDB entry)

13. Ta1064 (RFK), N-terminal domain [158274] (1 species)

    • Species Thermoplasma acidophilum [TaxId:2303] [158275] (1 PDB entry)
      Uniprot Q9HJA6 5-89

14. Transcriptional regulator DR1159 [140255] (1 species)

    • Species Deinococcus radiodurans [TaxId:1299] [140256] (1 PDB entry)
      Uniprot Q9RV71 8-179

15. Transcriptional regulator MgrA [158272] (1 species)

    • Species Staphylococcus aureus [TaxId:1280] [158273] (1 PDB entry)
      Uniprot Q7A1J9 6-141

16. Transcriptional regulator OEOE1854 [158276] (1 species)

    • Species Oenococcus oeni [TaxId:1247] [158277] (1 PDB entry)
      Uniprot Q04CY6 3-137

17. Transcriptional regulator PA3341 [140249] (1 species)

    • Species Pseudomonas aeruginosa [TaxId:287] [140250] (1 PDB entry)
      Uniprot Q9HYQ4 8-144

18. Transcriptional regulator SlyA [81688] (2 species)

    1. Species Enterococcus faecalis [TaxId:1351] [81689] (1 PDB entry)

    2. Species Salmonella typhimurium [TaxId:90371] [158271] (3 PDB entries)
       Uniprot P40676 1-140

19. Transcriptional regulator TM0710 [140253] (1 species)

    • Species Thermotoga maritima [TaxId:2336] [140254] (1 PDB entry)
      Uniprot Q9WZG9 5-143

20. automated matches [190294] (4 species)
    not a true protein

    1. Species Deinococcus radiodurans [TaxId:1299] [187697] (1 PDB entry)

    2. Species Escherichia coli [TaxId:83333] [193218] (3 PDB entries)

    3. Species Thermotoga maritima [TaxId:2336] [187380] (1 PDB entry)

    4. Species Yersinia pseudotuberculosis [TaxId:502800] [193529] (1 PDB entry)

More info for Family a.4.5.28: MarR-like transcriptional regulators

Timeline for Family a.4.5.28: MarR-like transcriptional regulators:

• Family a.4.5.28: MarR-like transcriptional regulators first appeared in SCOP 1.57
  
• Family a.4.5.28: MarR-like transcriptional regulators appears in SCOPe 2.01
  
• Family a.4.5.28: MarR-like transcriptional regulators appears in SCOPe 2.03
  
• Family a.4.5.28: MarR-like transcriptional regulators appears in the current release, SCOPe 2.08