SCOPe 2.07: Domain d1iqda2: 1iqd A:109-212

Lineage for d1iqda2 (1iqd A:109-212)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (151 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d1iqda2: 1iqd A:109-212 [62645]
   Other proteins in same PDB: d1iqda1, d1iqdb1, d1iqdb2, d1iqdc_
   part of Fab BO2C11 against the C2 domain of factor VIII

Details for d1iqda2

PDB Entry: 1iqd, 2 Å

PDB Description: human factor viii c2 domain complexed to human monoclonal bo2c11 fab.

PDB Compounds: (A:) human monoclonal bo2c11 fab light chain

SCOPe Domain Sequences for d1iqda2:

Sequence, based on SEQRES records:

>d1iqda2 b.1.1.2 (A:109-212) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
gtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnr

Sequence, based on observed residues (ATOM records):

>d1iqda2 b.1.1.2 (A:109-212) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
gtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglvtksfnr

Timeline for d1iqda2:

• d1iqda2 first appeared in SCOP 1.57
  
• d1iqda2 appears in SCOPe 2.06
  
• d1iqda2 appears in the current release, SCOPe 2.08