SCOPe 2.08: Domain d1i7zc2: 1i7z C:108-214

Lineage for d1i7zc2 (1i7z C:108-214)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (147 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d1i7zc2: 1i7z C:108-214 [61924]
   Other proteins in same PDB: d1i7za1, d1i7zb1, d1i7zb2, d1i7zb3, d1i7zc1, d1i7zd1, d1i7zd2, d1i7zd3
   part of humanized Fab GNC92H2
   complexed with coc

Details for d1i7zc2

PDB Entry: 1i7z, 2.3 Å

PDB Description: antibody gnc92h2 bound to ligand

PDB Compounds: (C:) chimera of ig kappa chain: human constant region and mouse variable region

SCOPe Domain Sequences for d1i7zc2:

Sequence; same for both SEQRES and ATOM records:

>d1i7zc2 b.1.1.2 (C:108-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d1i7zc2:

• d1i7zc2 first appeared in SCOP 1.57
  
• d1i7zc2 appears in SCOPe 2.07