SCOP 1.73: Domain d1hysd1: 1hys D:1-123

Lineage for d1hysd1 (1hys D:1-123)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (27 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (29 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (20 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 6 [TaxId:10090] [88556] (12 PDB entries)

8. Domain d1hysd1: 1hys D:1-123 [61422]
   Other proteins in same PDB: d1hysa1, d1hysa2, d1hysb_, d1hysc1, d1hysc2, d1hysd2
   part of Fab 28 against HIV-1 RT
   mutant

Details for d1hysd1

PDB Entry: 1hys, 3 Å

PDB Description: crystal structure of hiv-1 reverse transcriptase in complex with a polypurine tract rna:dna

PDB Compounds: (D:) fab-28 monoclonal antibody fragment heavy chain

SCOP Domain Sequences for d1hysd1:

Sequence; same for both SEQRES and ATOM records:

>d1hysd1 b.1.1.1 (D:1-123) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 6 [TaxId: 10090]}
qitlkesgpgivqpsqpfrltctfsgfslstsgigvtwirqpsgkglewlatiwwdddnr
ynpslksrltvskdtsnnqaflnmmtvetadtaiyycaqsaitsvtdsamdhwgqgtsvt
vss

Timeline for d1hysd1:

• d1hysd1 first appeared in SCOP 1.57
  
• d1hysd1 appears in SCOP 1.71
  
• d1hysd1 appears in SCOP 1.75
  
• d1hysd1 appears in the current release, SCOPe 2.08