SCOP 1.69: Domain d1h8sb2: 1h8s B:133-243

Lineage for d1h8sb2 (1h8s B:133-243)

1. Root: SCOP 1.69

2. Class b: All beta proteins [48724] (144 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (23 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (27 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (20 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (143 PDB entries)

8. Domain d1h8sb2: 1h8s B:133-243 [60792]
   Other proteins in same PDB: d1h8sa1, d1h8sb1
   part of anti-ampicillin scFv

Details for d1h8sb2

PDB Entry: 1h8s, 2.4 Å

PDB Description: three-dimensional structure of anti-ampicillin single chain fv fragment complexed with the hapten.

SCOP Domain Sequences for d1h8sb2:

Sequence; same for both SEQRES and ATOM records:

>d1h8sb2 b.1.1.1 (B:133-243) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2}
vqlqepggelvrpgasvklsckasgytftsywinwvkqrpgqglewigniypsdsytnyn
qkfkdkatltvdkssstaymqlssltsedsavyfcarwgywgqgtlvtvsa

Timeline for d1h8sb2:

• d1h8sb2 first appeared in SCOP 1.57
  
• d1h8sb2 appears in SCOP 1.67
  
• d1h8sb2 appears in SCOP 1.71
  
• d1h8sb2 appears in the current release, SCOPe 2.08