SCOP 1.71: Domain d1h8na1: 1h8n A:3-109

Lineage for d1h8na1 (1h8n A:3-109)

1. Root: SCOP 1.71

2. Class b: All beta proteins [48724] (149 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (25 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (28 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (14 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88531] (170 PDB entries)

8. Domain d1h8na1: 1h8n A:3-109 [60783]
   Other proteins in same PDB: d1h8na2
   part of anti-ampicillin scFv
   complexed with gol, so4; mutant

Details for d1h8na1

PDB Entry: 1h8n, 1.87 Å

PDB Description: three-dimensional structure of anti-ampicillin single chain fv fragment from phage-displayed murine antibody libraries

SCOP Domain Sequences for d1h8na1:

Sequence; same for both SEQRES and ATOM records:

>d1h8na1 b.1.1.1 (A:3-109) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 4}
kdivltqshkfmstsvgdrvsitckasqdvgtavawyqqkpgqspklliywastrhtgvp
drftgsgsgtdftltisnvqsedladyfcqqyssypltfgagtklel

Timeline for d1h8na1:

• d1h8na1 first appeared in SCOP 1.57
  
• d1h8na1 appears in SCOP 1.69
  
• d1h8na1 appears in SCOP 1.73
  
• d1h8na1 appears in the current release, SCOPe 2.08