SCOPe 2.02: Domain d1fvra_: 1fvr A:

Lineage for d1fvra_ (1fvr A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tie2 kinase [64406] (1 species)
   PTK group; Tie/Tck subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [64407] (1 PDB entry)

8. Domain d1fvra_: 1fvr A: [60047]

Details for d1fvra_

PDB Entry: 1fvr, 2.2 Å

PDB Description: tie2 kinase domain

PDB Compounds: (A:) tyrosine-protein kinase tie-2

SCOPe Domain Sequences for d1fvra_:

Sequence, based on SEQRES records:

>d1fvra_ d.144.1.7 (A:) Tie2 kinase {Human (Homo sapiens) [TaxId: 9606]}
ptiypvldwndikfqdvigegnfgqvlkarikkdglrmdaaikrmkeyaskddhrdfage
levlcklghhpniinllgacehrgylylaieyaphgnlldflrksrvletdpafaianst
astlssqqllhfaadvargmdylsqkqfihrdlaarnilvgenyvakiadfglsrgqevy
vkktmgrlpvrwmaieslnysvyttnsdvwsygvllweivslggtpycgmtcaelyeklp
qgyrlekplncddevydlmrqcwrekpyerpsfaqilvslnrmleerktyvnttlyekft
yagidcsae

Sequence, based on observed residues (ATOM records):

>d1fvra_ d.144.1.7 (A:) Tie2 kinase {Human (Homo sapiens) [TaxId: 9606]}
ptiypvldwndikfqdvigegnfgqvlkarikkdglrmdaaikrmkeyrdfagelevlck
lghhpniinllgacehrgylylaieyaphgnlldflrksrvletdpafaianstastlss
qqllhfaadvargmdylsqkqfihrdlaarnilvgenyvakiadfglsrgqevyvkklpv
rwmaieslnysvyttnsdvwsygvllweivslggtpycgmtcaelyeklpqgyrlekpln
cddevydlmrqcwrekpyerpsfaqilvslnrmleerktyvnttlyekftyagidcsae

Timeline for d1fvra_:

• d1fvra_ first appeared in SCOP 1.57
  
• d1fvra_ appears in SCOPe 2.01
  
• d1fvra_ appears in SCOPe 2.03
  
• d1fvra_ appears in the current release, SCOPe 2.08