SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Protein: TGF-beta2

  1. Root: SCOPe 2.06
  2. 2229111Class g: Small proteins [56992] (94 folds)
  3. 2232568Fold g.17: Cystine-knot cytokines [57500] (1 superfamily)
    disulfide-rich fold; common core is all-beta
  4. 2232569Superfamily g.17.1: Cystine-knot cytokines [57501] (8 families) (S)
  5. 2232656Family g.17.1.2: Transforming growth factor (TGF)-beta [57507] (8 protein domains)
  6. 2232729Protein TGF-beta2 [57510] (2 species)

Species:

  1. 2232730Human (Homo sapiens) [TaxId:9606] [57511] (4 PDB entries)
    1. Domain for 1tfg:
    2. Domain for 2tgi:
    3. Domains for 4kxz:
      1. 2232733Domain d4kxza_: 4kxz A: [259785]
        Other proteins in same PDB: d4kxzi1, d4kxzi2, d4kxzl1, d4kxzl2, d4kxzm1, d4kxzm2, d4kxzp1, d4kxzp2
        automated match to d2tgia_
        complexed with mes, pe5
      2. 2232734Domain d4kxzb_: 4kxz B: [259782]
        Other proteins in same PDB: d4kxzi1, d4kxzi2, d4kxzl1, d4kxzl2, d4kxzm1, d4kxzm2, d4kxzp1, d4kxzp2
        automated match to d2tgia_
        complexed with mes, pe5
      3. 2232735Domain d4kxzd_: 4kxz D: [259784]
        Other proteins in same PDB: d4kxzi1, d4kxzi2, d4kxzl1, d4kxzl2, d4kxzm1, d4kxzm2, d4kxzp1, d4kxzp2
        automated match to d2tgia_
        complexed with mes, pe5
      4. 2232736Domain d4kxze_: 4kxz E: [259783]
        Other proteins in same PDB: d4kxzi1, d4kxzi2, d4kxzl1, d4kxzl2, d4kxzm1, d4kxzm2, d4kxzp1, d4kxzp2
        automated match to d2tgia_
        complexed with mes, pe5
    4. Domain for 5tx4:
  2. 2287150Mus musculus [TaxId:10090] [330451] (2 PDB entries)
    1. Domains for 5tx2:
      1. 2287213Domain d5tx2a_: 5tx2 A: [330514]
        automated match to d2tgia_
        mutant
      2. 2287227Domain d5tx2b_: 5tx2 B: [330528]
        automated match to d2tgia_
        mutant
    2. Domains for 5tx6:
      1. 2287151Domain d5tx6b_: 5tx6 B: [330452]
        automated match to d2tgia_
        complexed with ca; mutant
      2. 2287210Domain d5tx6a_: 5tx6 A: [330511]
        automated match to d2tgia_
        complexed with ca; mutant
      3. 2287253Domain d5tx6c_: 5tx6 C: [330554]
        automated match to d2tgia_
        complexed with ca; mutant

More info for Protein TGF-beta2 from g.17.1.2: Transforming growth factor (TGF)-beta

Timeline for Protein TGF-beta2 from g.17.1.2: Transforming growth factor (TGF)-beta: