SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family g.17.1.2: Transforming growth factor (TGF)-beta

  1. Root: SCOPe 2.06
  2. 2229111Class g: Small proteins [56992] (94 folds)
  3. 2232568Fold g.17: Cystine-knot cytokines [57500] (1 superfamily)
    disulfide-rich fold; common core is all-beta
  4. 2232569Superfamily g.17.1: Cystine-knot cytokines [57501] (8 families) (S)
  5. 2232656Family g.17.1.2: Transforming growth factor (TGF)-beta [57507] (8 protein domains)

Protein Domains:

  1. 2232657Activin A (Inhibin beta A) [90170] (1 species)
  2. 2232676Bone morphogenetic protein-2 (BMP-2) [57516] (1 species)
  3. 2232701Bone morphogenetic protein-7 (BMP-7) [57514] (1 species)
  4. 2232707Glial cell-derived neurotrophic factor, GDNF [57518] (1 species)
  5. 2232713TGF-beta1 [57512] (1 species)
  6. 2232729TGF-beta2 [57510] (2 species)
    1. 2232730Species Human (Homo sapiens) [TaxId:9606] [57511] (4 PDB entries)
    2. 2287150Species Mus musculus [TaxId:10090] [330451] (2 PDB entries)
  7. 2232737TGF-beta3 [57508] (1 species)
  8. 2232747automated matches [190307] (1 species)
    not a true protein

More info for Family g.17.1.2: Transforming growth factor (TGF)-beta

Timeline for Family g.17.1.2: Transforming growth factor (TGF)-beta: